Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 19/20 | 0.48 |
| ▸ | PDE4A | P27815 | 10/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2354086 | 1.00 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| SCHEMBL7360621 | 0.75 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL3441348 | 0.73 | KAT2B (0.58) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| SCHEMBL619603 | 0.72 | CA12 (0.53) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| SCHEMBL619604 | 0.72 | CA12 (0.53) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| SCHEMBL7362656 | 0.71 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL619683 | 0.71 | KAT2B (0.49) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| SCHEMBL7362118 | 0.71 | PDE4D (0.55) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL619682 | 0.71 | KAT2B (0.49) | PDE4DPDE4APDE4BPDE4CKAT2B | |
| SCHEMBL7353099 | 0.70 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536713-A1 | (R)-4-((4-((4-(TETRAHYDROFURAN-3-YLOXY)BENZO[D]ISOXAZOL-3-YLOXY)METHYL)PIPERIDIN-1-YL)METHYL)TETRAHYDRO-2H-PYRAN-4-OL, A PARTIAL AGONIST OF 5-HT4 RECEPTORS | Pfizer Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011101774-A1 | (R)-4-((4-((4-(TETRAHYDROFURAN-3-YLOXY)BENZO[D]ISOXAZOL-3-YLOXY)METHYL)PIPERIDIN-1-YL)METHYL)TETRAHYDRO-2H-PYRAN-4-OL, A PARTIAL AGONIST OF 5-HT4 RECEPTORS | PFIZER INC. (US) | 2011-08-25 | — | — | WO | disclosed |