Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20314873 | 1.00 | JAK3 (0.41) | JAK3PARP1PARP2OPRK1TEAD1 | |
| SCHEMBL23544835 | 0.88 | JAK3 (0.35) | JAK3OPRK1TEAD1 | |
| SCHEMBL20314864 | 0.88 | JAK3 (0.34) | JAK3OPRK1TEAD1 | |
| SCHEMBL25839519 | 0.88 | JAK3 (0.34) | JAK3OPRK1TEAD1 | |
| SCHEMBL20314921 | 0.86 | TEAD1 (0.34) | JAK3PARP1PARP2OPRK1TEAD1 | |
| SCHEMBL20314912 | 0.85 | KMT2A (0.44) | — | |
| SCHEMBL20314946 | 0.85 | TEAD1 (0.33) | JAK3OPRK1TEAD1 | |
| SCHEMBL20314896 | 0.85 | JAK3 (0.33) | JAK3OPRK1TEAD1 | |
| SCHEMBL22881071 | 0.84 | JAK3 (0.35) | JAK3PARP1PARP2 | |
| SCHEMBL23545019 | 0.84 | JAK3 (0.36) | JAK3OPRK1TEAD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11697648-B2 | Fused pyrimidine pyridinone compounds as JAK inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-07-11 | — | — | US | disclosed |
| US-11697648-B2 | Fused pyrimidine pyridinone compounds as JAK inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-07-11 | — | — | US | disclosed |
| US-20210188844-A1 | FUSED PYRIMIDINE PYRIDINONE COMPOUNDS AS JAK INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2021-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188844-A1 | FUSED PYRIMIDINE PYRIDINONE COMPOUNDS AS JAK INHIBITORS | JAK3, JAK1, JAK2 | JAK3 1/4885PARP1 3184/4885PARP2 3641/4885 |
| US-11697648-B2 | Fused pyrimidine pyridinone compounds as JAK inhibitors | JAK3, JAK1, JAK2 | JAK3 1/4885PARP1 3184/4885PARP2 3641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.