Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 7/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30999407 | 0.92 | EPHX1 (0.49) | EPHX1USP30HSD11B1CYP2C9ALDH1A1 | |
| SCHEMBL1990841 | 0.92 | USP30 (0.51) | EPHX1USP30ALDH1A1NR1H2MAPT | |
| SCHEMBL948136 | 0.91 | EPHX1 (0.57) | EPHX1ALDH1A1NR1H2MAPTNPC1 | |
| SCHEMBL18556969 | 0.90 | EPHX1 (0.52) | EPHX1USP30HSD11B1CYP2C9ALDH1A1 | |
| SCHEMBL13696753 | 0.90 | EPHX1 (0.52) | EPHX1USP30HSD11B1CYP2C9ALDH1A1 | |
| SCHEMBL25237250 | 0.90 | EPHX1 (0.52) | EPHX1USP30HSD11B1CYP2C9ALDH1A1 | |
| SCHEMBL2907249 | 0.88 | NR1H2 (0.53) | EPHX1USP30ALDH1A1NR1H2MAPT | |
| SCHEMBL31421132 | 0.87 | EPHX1 (0.53) | EPHX1USP30HSD11B1CYP2C9ALDH1A1 | |
| SCHEMBL24033437 | 0.86 | EPHX1 (0.49) | EPHX1USP30HSD11B1CYP2C9ALDH1A1 | |
| SCHEMBL13712553 | 0.86 | USP30 (0.49) | EPHX1USP30HSD11B1CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021121363-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-24 | — | — | WO | disclosed |