Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 16/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 16/20 | 0.39 |
| ▸ | GAA | P10253 | 12/20 | 0.39 |
| ▸ | HPGD | P15428 | 11/20 | 0.39 |
| ▸ | GLA | P06280 | 9/20 | 0.39 |
| ▸ | CASP1 | P29466 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | CASP7 | P55210 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25863774 | 0.90 | MAPT (0.42) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL25856818 | 0.88 | ATM (0.38) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL25856710 | 0.86 | CNR1 (0.36) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL25856799 | 0.80 | KDM4E (0.37) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL25863238 | 0.70 | CXCR1 (0.40) | ALDH1A1HPGDSMN1; SMN2CNR1CNR2 | |
| SCHEMBL25856813 | 0.69 | EPHX2 (0.41) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL25857451 | 0.69 | KDM4E (0.45) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL23524290 | 0.69 | MAPT (0.54) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL30355741 | 0.69 | MAPT (0.54) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL25856722 | 0.68 | KDM4E (0.39) | KDM4EALDH1A1GAAHPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234946-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | TREVENA, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20210188826-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | TREVENA, INC. | 2021-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234946-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | S1PR1, S1PR2, S1PR3 | KDM4E 2644/4885ALDH1A1 2583/4885GAA 3859/4885 |
| US-20210188826-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | S1PR1, S1PR2, S1PR3 | KDM4E 2644/4885ALDH1A1 2583/4885GAA 3859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.