Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.56 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | TNF | P01375 | 1/20 | 0.55 |
| ▸ | IL1B | P01584 | 1/20 | 0.55 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.55 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.46 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23066003 | 0.89 | CRBN (0.57) | CRBNIKZF3DDB1BRD4TNF | |
| SCHEMBL30270624 | 0.89 | CRBN (0.57) | CRBNIKZF3DDB1BRD4TNF | |
| SCHEMBL30270628 | 0.86 | CRBN (0.55) | CRBNIKZF3DDB1BRD4TNF | |
| SCHEMBL19451306 | 0.86 | CRBN (0.55) | CRBNIKZF3DDB1BRD4TNF | |
| SCHEMBL30270923 | 0.86 | CRBN (0.55) | CRBNIKZF3DDB1BRD4TNF | |
| SCHEMBL30270976 | 0.86 | CRBN (0.55) | CRBNIKZF3DDB1BRD4TNF | |
| SCHEMBL25012124 | 0.86 | CRBN (0.55) | CRBNIKZF3DDB1BRD4TNF | |
| SCHEMBL23065995 | 0.86 | CRBN (0.55) | CRBNIKZF3DDB1BRD4TNF | |
| SCHEMBL25650356 | 0.86 | CRBN (0.55) | CRBNIKZF3DDB1BRD4TNF | |
| SCHEMBL27091825 | 0.86 | CRBN (0.55) | CRBNIKZF3DDB1BRD4TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021126974-A1 | BIFUNCTIONAL AGENTS FOR PROTEIN RECRUITMENT AND/OR DEGRADATION | ORIONIS BIOSCIENCES, INC. (US) | 2021-06-24 | — | — | WO | disclosed |