Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.70 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.53 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | IL1B | P01584 | 1/20 | 0.53 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23534326 | 0.87 | CRBN (0.71) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL29791157 | 0.87 | CRBN (0.71) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL23565612 | 0.85 | CRBN (0.69) | CRBN | |
| SCHEMBL23565611 | 0.84 | CRBN (0.65) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL19556665 | 0.83 | CRBN (1.00) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL19556664 | 0.83 | CRBN (1.00) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL27097754 | 0.83 | CRBN (1.00) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL476917 | 0.83 | CRBN (1.00) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL24186805 | 0.82 | CRBN (0.75) | CRBN | |
| SCHEMBL23564835 | 0.82 | CRBN (0.66) | CRBNDDB1IKZF3BRD4TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021126974-A1 | BIFUNCTIONAL AGENTS FOR PROTEIN RECRUITMENT AND/OR DEGRADATION | ORIONIS BIOSCIENCES, INC. (US) | 2021-06-24 | — | — | WO | disclosed |