Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 14/20 | 0.49 |
| ▸ | FYN | P06241 | 4/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12351021 | 1.00 | PIM1 (0.49) | PIM1FYNMKNK1PIM3PIM2 | |
| SCHEMBL12350723 | 0.89 | PIM1 (0.51) | PIM1FYNMKNK1PIM3PIM2 | |
| SCHEMBL12351049 | 0.86 | PIM1 (0.50) | PIM1FYNMKNK1PIM3PIM2 | |
| SCHEMBL2237814 | 0.86 | PIM1 (0.47) | PIM1FYNMKNK1KCNH2 | |
| SCHEMBL12351067 | 0.86 | PIM1 (0.53) | PIM1FYNMKNK1KCNH2 | |
| SCHEMBL2358340 | 0.86 | PIM1 (0.53) | PIM1FYNMKNK1KCNH2 | |
| SCHEMBL12350791 | 0.84 | PIM1 (0.49) | PIM1FYNPIM3PIM2 | |
| SCHEMBL12351050 | 0.84 | PIM1 (0.46) | PIM1FYNMKNK1PIM3PIM2 | |
| SCHEMBL12351087 | 0.84 | PIM1 (0.46) | PIM1MKNK1PIM3PIM2KCNH2 | |
| SCHEMBL2355941 | 0.84 | PIM1 (0.46) | PIM1MKNK1PIM3PIM2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350085-A1 | QUINAZOLINONE LINKED PYRROLOÝ2,1 -C¨Ý1.4¨BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FORTHE PREPARATION THEREOF | Council Of Scientific & Industrial Research (IN) | 2011-08-03 | — | — | EP | claimed |
| WO-2010058416-A1 | QUINAZOLINONE LINKED PYRROLO[2,1 -C][1.4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FORTHE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-05-27 | — | — | WO | claimed |
| WO-2011101640-A1 | FUSED HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF MALARIA | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2011-08-25 | — | — | WO | disclosed |