Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27425335 | 0.85 | HRH3 (0.37) | HRH3 | |
| SCHEMBL23945992 | 0.84 | NPC1 (0.40) | NPC1HRH3CARM1PRMT6 | |
| SCHEMBL24764415 | 0.84 | NPC1 (0.35) | NPC1HRH3CARM1PRMT6ADRB2 | |
| SCHEMBL24672510 | 0.83 | NPC1 (0.34) | NPC1HRH3CARM1PRMT6ADRB2 | |
| SCHEMBL22848886 | 0.83 | HRH3 (0.38) | NPC1HRH3CARM1PRMT6ADRB2 | |
| SCHEMBL26822230 | 0.81 | CARM1 (0.41) | NPC1NMT1HRH3CARM1PRMT6 | |
| SCHEMBL26408395 | 0.80 | HRH3 (0.35) | NPC1HRH3NAMPTCARM1PRMT6 | |
| SCHEMBL24673656 | 0.80 | HRH3 (0.33) | NPC1HRH3CARM1PRMT6HTR1B | |
| SCHEMBL25123461 | 0.80 | HRH3 (0.33) | NPC1HRH3CARM1PRMT6HTR1B | |
| SCHEMBL24673386 | 0.80 | NPC1 (0.39) | NPC1HRH3CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127190-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |