Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23534532 | 0.81 | RXFP1 (0.53) | HSD17B10L3MBTL1MEN1KMT2ATSHR | |
| SCHEMBL23534425 | 0.80 | RXFP1 (0.41) | HSD17B10MEN1KMT2ARXFP1CYP3A4 | |
| SCHEMBL23534436 | 0.80 | RXFP1 (0.41) | HSD17B10KMT2ARXFP1ADORA2APKM | |
| SCHEMBL31210519 | 0.71 | RXFP1 (0.38) | L3MBTL1TSHRRXFP1CYP3A4CYP2C9 | |
| SCHEMBL25341208 | 0.71 | PIK3R1 (0.46) | HSD17B10MEN1KMT2ATSHRKDM4E | |
| SCHEMBL31695060 | 0.70 | HSD17B10 (0.58) | HSD17B10L3MBTL1MEN1KMT2ATSHR | |
| SCHEMBL26926119 | 0.70 | HSD17B10 (0.58) | HSD17B10L3MBTL1MEN1KMT2ATSHR | |
| SCHEMBL4891536 | 0.69 | RXFP1 (0.41) | HSD17B10L3MBTL1MEN1KMT2ATSHR | |
| SCHEMBL31211289 | 0.68 | CYP3A4 (0.39) | L3MBTL1TSHRRXFP1LMNAPDE10A | |
| SCHEMBL23571661 | 0.68 | RXFP1 (0.60) | L3MBTL1TSHRRXFP1NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021126729-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |