Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 5/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | NPY2R | P49146 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2359384 | 0.90 | AKT1 (0.42) | GAAGRM5GRM1AKT1LMNA | |
| SCHEMBL1425424 | 0.81 | KCNN4 (0.44) | KCNN4ALDH1A1 | |
| SCHEMBL1425298 | 0.80 | KCNN4 (0.46) | KCNN4ALDH1A1 | |
| SCHEMBL1425971 | 0.78 | KCNN4 (0.38) | KCNN4ALDH1A1 | |
| SCHEMBL2358883 | 0.78 | KCNN4 (0.46) | KCNN4ALDH1A1 | |
| SCHEMBL983904 | 0.77 | KCNN4 (0.50) | KCNN4 | |
| SCHEMBL2359723 | 0.76 | BACE1 (0.38) | LMNASMN1; SMN2 | |
| SCHEMBL987754 | 0.76 | KCNN4 (0.47) | KCNN4ALDH1A1 | |
| SCHEMBL2359902 | 0.72 | RET (0.49) | — | |
| SCHEMBL982800 | 0.72 | KCNN4 (0.46) | KCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350045-A1 | C-MET PROTEIN KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010048131-A1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-29 | — | — | WO | disclosed |