SCHEMBL2358166

SCHEMBL2358166

Nc1ccc(C=CC(=O)C=Cc2ccc(N)cc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F3 P13726 3/20 0.64
HSD11B1 P28845 2/20 0.64
CYP2D6 P10635 2/20 0.64
CYP2C9 P11712 2/20 0.64
TYR P14679 1/20 0.64
CYP1A2 P05177 4/20 0.61
MAPT P10636 4/20 0.60
ALDH1A1 P00352 2/20 0.60
LMNA P02545 2/20 0.60
SMN1; SMN2 Q16637 2/20 0.60
PLIN1 O60240 1/20 0.60
RECQL P46063 1/20 0.60
PLIN5 Q00G26 1/20 0.60
ABHD5 Q8WTS1 1/20 0.60
NFKB1 P19838 3/20 0.56
JUN P05412 1/20 0.56
HSD17B3 P37058 1/20 0.55
CYP1B1 Q16678 1/20 0.55
APP P05067 2/20 0.54
MEN1 O00255 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2358165 1.00 F3 (0.64) F3HSD11B1CYP2D6CYP2C9TYR
SCHEMBL28741093 0.87 F3 (0.50) F3HSD11B1CYP2D6CYP2C9TYR
SCHEMBL31574371 0.86 CYP1B1 (0.55) F3HSD11B1CYP2D6CYP2C9TYR
SCHEMBL7558225 0.84 CYP1B1 (0.53) F3HSD11B1CYP2D6CYP2C9TYR
SCHEMBL143559 0.84 CA12 (0.65) CYP2C9TYRMAPTALDH1A1LMNA
SCHEMBL7558227 0.84 CYP1B1 (0.53) F3HSD11B1CYP2D6CYP2C9TYR
SCHEMBL1001682 0.84 CA12 (0.65) CYP2C9TYRMAPTALDH1A1LMNA
SCHEMBL143558 0.84 CA12 (0.65) CYP2C9TYRMAPTALDH1A1LMNA
SCHEMBL23260961 0.82 CA12 (0.56) F3HSD11B1CYP2D6CYP2C9TYR
SCHEMBL10930359 0.82 GLA (0.63) F3HSD11B1CYP2D6CYP2C9TYR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7740482-B2 Stable cationically crosslinkable/polymerizable dental composition with a high filler content BLUESTAR SILICONES FRANCE (FR) 2010-06-22 US claimed
EP-1745083-B1 HIGHLY-CHARGED STABLE DENTAL COMPOSITION WHICH MAY BE CROSS-LINKED/POLYMERISED BY CATIONIC REACTION BLUESTAR SILICONES FRANCE (FR) 2009-12-16 EP claimed
US-20080287562-A1 Stable cationically crosslinkable/polymerizable dental composition with a high filler content RHODIA CHIMIE (FR) 2008-11-20 US claimed
US-20050261390-A1 Stable cationically crosslinkable/polymerizable dental composition with a high filler content RHODIA CHIMIE (FR) 2005-11-24 US claimed
EP-0068808-B1 PHOTORESIST COMPOSITION JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1985-06-05 EP claimed
US-4407927-A ANTIHALATION AGENT JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1983-10-04 US claimed
EP-0068808-A2 Photoresist composition JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1983-01-05 EP claimed
WO-2024156230-A1 FULL-BIO-BASED ARYL DIAMINE FLAME RETARDANT AND FULL-BIO-BASED ARYL DIAMINE POLYIMIDE THIN FILM 南京工业大学 2024-08-02 WO disclosed
CN-116621719-B Synthesis method of full-biology-based aryl diamine chain extender applied to preparation of polyurethane 南京工业大学 2024-01-30 CN disclosed
CN-117304487-A Full-biological aryl diamine polyimide film and preparation method thereof 南京工业大学 2023-12-29 CN disclosed
CN-116621719-A Synthesis method of full-biology-based aryl diamine chain extender applied to preparation of polyurethane 南京工业大学 2023-08-22 CN disclosed
CN-114591188-B All-biological-based aryl diamine chain extender, and preparation method and application thereof 南京工业大学 2023-06-09 CN disclosed
CN-114591188-A Full-bio-based aryl diamine chain extender and preparation method and application thereof 南京工业大学 2022-06-07 CN disclosed
EP-0980016-B1 ALIGNING AGENT FOR LIQUID CRYSTAL NISSAN CHEMICAL IND LTD (JP) 2008-09-24 EP disclosed
US-20050261390-A1 Stable cationically crosslinkable/polymerizable dental composition with a high filler content RHODIA CHIMIE (FR) 2005-11-24 US disclosed
US-6274695-B1 THIN FILM POLYMER NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2001-08-14 US disclosed
EP-0980016-A1 ALIGNING AGENT FOR LIQUID CRYSTAL Nissan Chemical Industries, Ltd. (JP) 2000-02-16 EP disclosed
EP-0068808-B1 PHOTORESIST COMPOSITION JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1985-06-05 EP disclosed
US-4407927-A ANTIHALATION AGENT JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1983-10-04 US disclosed
EP-0068808-A2 Photoresist composition JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1983-01-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080287562-A1 Stable cationically crosslinkable/polymerizable dental composition with a high filler content RFC1, RFC2, HNRNPC F3 216/4885HSD11B1 4166/4885CYP2D6 2936/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.