Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.40 |
| ▸ | SRC | P12931 | 4/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | ABL2 | P42684 | 1/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.35 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584745 | 0.97 | PRMT5 (0.40) | PRMT5WDR77SRCTGFBR1EGFR | |
| SCHEMBL23584746 | 0.96 | PRMT5 (0.39) | PRMT5WDR77SRCTGFBR1EGFR | |
| SCHEMBL19344269 | 0.95 | PRMT5 (0.39) | PRMT5WDR77SRCTGFBR1EGFR | |
| SCHEMBL23584477 | 0.88 | NAMPT (0.39) | PRMT5WDR77SRCTGFBR1EGFR | |
| SCHEMBL23584483 | 0.88 | NAMPT (0.36) | GPR119NAMPT | |
| SCHEMBL23584528 | 0.88 | PRMT5 (0.43) | PRMT5WDR77SRCTGFBR1EGFR | |
| SCHEMBL23584593 | 0.87 | NAMPT (0.37) | GPR119NAMPT | |
| SCHEMBL23584556 | 0.87 | NAMPT (0.40) | PRMT5WDR77SRCTGFBR1EGFR | |
| SCHEMBL23584669 | 0.87 | JAK3 (0.45) | PRMT5WDR77SRCTGFBR1EGFR | |
| SCHEMBL23584608 | 0.86 | SRC (0.38) | PRMT5WDR77SRCTGFBR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |