Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 16/20 | 0.65 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.65 |
| ▸ | METTL3 | Q86U44 | 3/20 | 0.42 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344181 | 0.97 | PRMT5 (0.68) | PRMT5WDR77METTL3ADKMEN1 | |
| SCHEMBL23584742 | 0.95 | PRMT5 (0.66) | PRMT5WDR77METTL3ADKMEN1 | |
| SCHEMBL23584869 | 0.94 | PRMT5 (0.60) | PRMT5WDR77METTL3ADKMEN1 | |
| SCHEMBL23584498 | 0.88 | PRMT5 (0.57) | PRMT5WDR77METTL3ADKMEN1 | |
| SCHEMBL19344159 | 0.88 | PRMT5 (0.54) | PRMT5WDR77METTL3ADKMEN1 | |
| SCHEMBL23584850 | 0.88 | PRMT5 (0.54) | PRMT5WDR77METTL3ADKMEN1 | |
| SCHEMBL23584844 | 0.86 | PRMT5 (0.56) | PRMT5WDR77METTL3ADKMEN1 | |
| SCHEMBL19344168 | 0.86 | PRMT5 (0.68) | PRMT5WDR77METTL3ADK | |
| SCHEMBL23584842 | 0.86 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL23584492 | 0.84 | PRMT5 (0.51) | PRMT5WDR77METTL3ADKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |