Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 14/20 | 0.81 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.81 |
| ▸ | ADK | P55263 | 1/20 | 0.55 |
| ▸ | METTL3 | Q86U44 | 5/20 | 0.54 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344092 | 0.93 | PRMT5 (0.71) | PRMT5WDR77ADKMETTL3DNMT1 | |
| SCHEMBL23584870 | 0.93 | PRMT5 (0.75) | PRMT5WDR77ADKMETTL3DNMT1 | |
| SCHEMBL19344085 | 0.92 | PRMT5 (0.97) | PRMT5WDR77ADKMETTL3DNMT1 | |
| SCHEMBL19344175 | 0.90 | PRMT5 (1.00) | PRMT5WDR77ADKMETTL3DNMT1 | |
| SCHEMBL19344096 | 0.89 | PRMT5 (0.66) | PRMT5WDR77ADKMETTL3DNMT1 | |
| SCHEMBL19344242 | 0.87 | PRMT5 (0.95) | PRMT5WDR77ADKMETTL3DNMT1 | |
| SCHEMBL19344084 | 0.85 | PRMT5 (0.84) | PRMT5WDR77ADKMETTL3DNMT1 | |
| SCHEMBL22435044 | 0.85 | PRMT5 (0.84) | PRMT5WDR77ADKMETTL3DNMT1 | |
| SCHEMBL19344241 | 0.85 | PRMT5 (0.90) | PRMT5WDR77ADKMETTL3DNMT1 | |
| SCHEMBL19344118 | 0.84 | PRMT5 (0.66) | PRMT5WDR77ADKMETTL3DNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |