Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.56 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.47 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | PNP | P00491 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344019 | 0.85 | PRMT5 (0.77) | PRMT5WDR77SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL19344532 | 0.81 | PRMT5 (0.77) | PRMT5WDR77SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL19344073 | 0.80 | PRMT5 (0.81) | PRMT5WDR77SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL19344531 | 0.80 | PRMT5 (0.79) | PRMT5WDR77SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL23584811 | 0.79 | PRMT5 (0.50) | PRMT5WDR77TP53CYP2C9NFKB1 | |
| SCHEMBL23584796 | 0.79 | PRMT5 (0.52) | PRMT5WDR77TP53SMN1; SMN2CYP2C9 | |
| SCHEMBL19344077 | 0.79 | PRMT5 (0.54) | PRMT5WDR77TP53CYP2C9NFKB1 | |
| SCHEMBL19344060 | 0.78 | PRMT5 (0.75) | PRMT5WDR77SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL12837026 | 0.76 | POLB (0.62) | POLBENPP1P2RY1HIF1ATP53 | |
| SCHEMBL14639883 | 0.76 | POLB (0.62) | POLBENPP1P2RY1HIF1ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |