Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15661458 | 0.90 | PDE4B (0.69) | PDE4BCYP3A4CYP2C19PDE4DPOLB | |
| SCHEMBL20525285 | 0.86 | PDE4B (0.65) | PDE4BCYP3A4CYP2C19PDE4DPOLB | |
| SCHEMBL16669198 | 0.82 | PDE4B (0.69) | PDE4BCYP3A4CYP2C19PDE4D | |
| SCHEMBL15661652 | 0.81 | PDE4B (0.70) | PDE4BCYP3A4CYP2C19PDE4D | |
| SCHEMBL18833254 | 0.80 | PDE4B (0.60) | PDE4BCYP3A4CYP2C19PDE4DTP53 | |
| SCHEMBL23586141 | 0.79 | PDE4B (0.55) | PDE4BCYP3A4CYP2C19PDE4D | |
| SCHEMBL16669360 | 0.78 | PDE4B (0.54) | PDE4BCYP3A4CYP2C19PDE4D | |
| SCHEMBL15947965 | 0.78 | PDE4B (0.57) | PDE4BCYP3A4CYP2C19PDE4D | |
| SCHEMBL15947883 | 0.77 | PDE4B (0.53) | PDE4BCYP3A4CYP2C19PDE4D | |
| SCHEMBL23586185 | 0.77 | PDE4B (0.53) | PDE4BCYP3A4CYP2C19PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3842420-B1 | HETEROARYL INHIBITORS OF PDE4 | TETRA DISCOVERY PARTNERS LLC (US) | 2022-12-07 | — | — | EP | disclosed |
| EP-3842420-A1 | HETEROARYL INHIBITORS OF PDE4 | Tetra Discovery Partners LLC (US) | 2021-06-30 | — | — | EP | disclosed |