Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23586227 | 0.94 | PDE4B (0.53) | PDE4BPDE4DTGFBR1 | |
| SCHEMBL23586150 | 0.86 | PDE4B (0.54) | PDE4BPDE4D | |
| SCHEMBL23586140 | 0.82 | PDE4B (0.51) | PDE4BPDE4D | |
| SCHEMBL23586147 | 0.82 | PDE4B (0.56) | PDE4BPDE4D | |
| SCHEMBL15947945 | 0.81 | PDE4B (0.67) | PDE4BPDE4D | |
| SCHEMBL23586222 | 0.81 | PDE4B (0.55) | PDE4BPDE4D | |
| SCHEMBL23586289 | 0.81 | PDE4B (0.52) | PDE4BPDE4DTGFBR1 | |
| SCHEMBL15658133 | 0.81 | PDE4B (0.69) | PDE4BPDE4D | |
| SCHEMBL23586158 | 0.80 | PDE4B (0.44) | PDE4BPDE4D | |
| SCHEMBL15659184 | 0.79 | PDE4B (0.54) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3842420-B1 | HETEROARYL INHIBITORS OF PDE4 | TETRA DISCOVERY PARTNERS LLC (US) | 2022-12-07 | — | — | EP | disclosed |
| EP-3842420-A1 | HETEROARYL INHIBITORS OF PDE4 | Tetra Discovery Partners LLC (US) | 2021-06-30 | — | — | EP | disclosed |