Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 7/20 | 0.46 |
| ▸ | F2 | P00734 | 6/20 | 0.46 |
| ▸ | PLG | P00747 | 6/20 | 0.46 |
| ▸ | PLAT | P00750 | 6/20 | 0.46 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | NPR3 | P17342 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16143958 | 0.90 | PLAU (0.61) | PLAUF2PLGPLATF10 | |
| SCHEMBL2249559 | 0.87 | PLAU (0.62) | PLAUF2PLGPLATF10 | |
| SCHEMBL2246863 | 0.85 | PLAU (0.65) | PLAUF2PLGPLATF10 | |
| SCHEMBL2364237 | 0.81 | ANPEP (0.39) | PLAUITGB1ITGB3ITGAVITGA2B | |
| SCHEMBL2242826 | 0.78 | PLAU (0.58) | PLAUF2PLGPLATF10 | |
| SCHEMBL13738443 | 0.78 | PLAU (0.49) | PLAUF2PLGPLATF10 | |
| SCHEMBL2242322 | 0.77 | F2 (0.39) | PLAUF2PLGPLATF10 | |
| SCHEMBL2242623 | 0.76 | PLAU (0.60) | PLAUF2PLGPLATF10 | |
| SCHEMBL2246988 | 0.76 | PLAU (0.59) | PLAUF2PLGPLATF10 | |
| SCHEMBL2243171 | 0.75 | PLAU (0.57) | PLAUF2PLGPLATF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003627-B2 | Urokinase inhibitors | UNIVERSITEIT ANTWERPEN (BE) | 2011-08-23 | — | — | US | disclosed |
| US-20080312191-A1 | Novel Urokinase Inhibitors | UNIVERSITEIT ANTWERPEN (BE) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312191-A1 | Novel Urokinase Inhibitors | PLAU, PLAUR, SERPINE1 | PLAU 1/4885F2 241/4885PLG 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.