Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 12/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 3/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12350844 | 1.00 | PIM1 (0.58) | PIM1CCNE1CDK2FLT3FYN | |
| SCHEMBL12351084 | 1.00 | PIM1 (0.58) | PIM1CCNE1CDK2FLT3FYN | |
| SCHEMBL16009992 | 0.86 | PIM1 (0.60) | PIM1CDK2FLT3FYNMKNK1 | |
| SCHEMBL1054446 | 0.86 | PIM1 (0.60) | PIM1CDK2FLT3FYNMKNK1 | |
| SCHEMBL1051076 | 0.86 | MKNK1 (0.63) | PIM1FYNMKNK1KCNH2MALT1 | |
| SCHEMBL1049252 | 0.84 | FYN (0.65) | PIM1FYNMKNK1KCNH2MALT1 | |
| SCHEMBL12351207 | 0.84 | MKNK1 (0.48) | PIM1FLT3FYNMKNK1KCNH2 | |
| SCHEMBL29926159 | 0.83 | MKNK1 (0.46) | PIM1FYNMKNK1KCNH2MALT1 | |
| SCHEMBL3204659 | 0.83 | PIM1 (0.62) | PIM1FYNMKNK1KCNH2MALT1 | |
| SCHEMBL2355377 | 0.83 | FYN (0.47) | PIM1FYNMKNK1KCNH2MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101640-A1 | FUSED HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF MALARIA | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2011-08-25 | — | — | WO | disclosed |