Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.56 |
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14717890 | 0.91 | LCK (0.59) | LCKMAPK14KITSRCRAF1 | |
| SCHEMBL2314975 | 0.86 | RAF1 (0.63) | LCKMAPK14KITSRCRAF1 | |
| SCHEMBL12432525 | 0.86 | LCK (0.61) | LCKMAPK14KITSRCRAF1 | |
| SCHEMBL2359154 | 0.84 | LCK (0.58) | LCKMAPK14KITSRCRAF1 | |
| SCHEMBL12432594 | 0.83 | LCK (0.57) | LCKMAPK14KITSRCRAF1 | |
| SCHEMBL2314225 | 0.82 | LCK (0.56) | LCKMAPK14KITSRCRAF1 | |
| SCHEMBL2315495 | 0.82 | SRC (0.57) | LCKMAPK14KITSRCRAF1 | |
| SCHEMBL2314639 | 0.81 | MAPK14 (0.57) | LCKMAPK14KITSRCRAF1 | |
| SCHEMBL12432595 | 0.81 | BRAF (0.57) | LCKMAPK14KITSRCRAF1 | |
| SCHEMBL12433876 | 0.80 | BRAF (0.60) | LCKMAPK14KITSRCRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528925-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | Hanmi Science Co., Ltd. (KR) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011093684-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-04 | — | — | WO | disclosed |