Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 15/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1783963 | 0.87 | PIK3CG (0.64) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL2958630 | 0.87 | PIK3CG (0.58) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL2324076 | 0.83 | PIK3CG (0.49) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL12991130 | 0.83 | PIK3CG (0.53) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL1886949 | 0.83 | PIK3CG (0.49) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL2323047 | 0.82 | PIK3CG (0.51) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL2329878 | 0.81 | PIK3CG (0.49) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL2361231 | 0.80 | PIK3CG (0.48) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL2360347 | 0.78 | PIK3CG (0.48) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL2359167 | 0.77 | PIK3CD (0.54) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2357179-A1 | Thiazol-2-yl organic compounds | Novartis AG (CH) | 2011-08-17 | — | — | EP | claimed |
| US-7754746-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-07-13 | — | — | US | claimed |
| CN-101374823-A | Organic compounds | NOVARTIS AG (CH) | 2009-02-25 | — | — | CN | claimed |
| US-20080319033-A1 | 3-{3-[5-(4-acetylphenyl)-4-methylthiazol-2-yl]-ureido}-N-tert-butylpropionamide, exhibiting phosphatidylinositol 3-kinase inhibitory activity and used for treating respiratory system disorders, such as asthma | NOVARTIS AG | 2008-12-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319033-A1 | 3-{3-[5-(4-acetylphenyl)-4-methylthiazol-2-yl]-ureido}-N-tert-butylpropionamide, exhibiting phosphatidylinositol 3-kinase inhibitory activity and used for treating respiratory system disorders, such as asthma | AKT3, PIK3R3, PIK3CD | PIK3CG 10/4885PIK3CA 4/4885PIK3CD 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.