Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 11/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.38 |
| ▸ | FEN1 | P39748 | 3/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2318560 | 0.88 | NR1H2 (0.66) | NR1H2NR1H3 | |
| SCHEMBL2359274 | 0.88 | NR1H2 (0.51) | NR1H2NR1H3PTPN1ALOX5APFEN1 | |
| SCHEMBL2319295 | 0.82 | NR1H2 (0.69) | NR1H2NR1H3 | |
| SCHEMBL2319004 | 0.81 | NR1H2 (0.71) | NR1H2NR1H3 | |
| SCHEMBL2359416 | 0.80 | NR1H2 (0.48) | NR1H2NR1H3ALOX5APFEN1 | |
| SCHEMBL2323639 | 0.80 | NR1H2 (0.62) | NR1H2NR1H3 | |
| SCHEMBL2358913 | 0.80 | NR1H2 (0.45) | NR1H2NR1H3ALOX5APFEN1 | |
| SCHEMBL3490930 | 0.80 | NR1H2 (0.78) | NR1H2NR1H3 | |
| SCHEMBL2323837 | 0.79 | NR1H2 (0.65) | NR1H2NR1H3 | |
| SCHEMBL2358272 | 0.79 | NR1H2 (0.40) | NR1H2NR1H3ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2352725-A1 | QUINOXALINE-BASED LXR MODULATORS | Wyeth LLC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2010054229-A1 | QUINOXALINE-BASED LXR MODULATORS | WYETH LLC (US) | 2010-05-14 | — | — | WO | disclosed |