Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 17/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.43 |
| ▸ | PRKDC | P78527 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.41 |
| ▸ | CLK2 | P49760 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.33 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2329878 | 0.86 | PIK3CG (0.49) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL2325802 | 0.82 | PIK3CG (0.56) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL2953327 | 0.82 | PIK3CG (0.49) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL12991160 | 0.82 | PIK3CG (0.58) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL2327763 | 0.81 | PIK3CG (0.48) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL2954498 | 0.81 | PIK3CG (0.48) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL2260708 | 0.81 | PIK3CG (0.63) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL2955998 | 0.81 | PIK3CG (0.46) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL2961266 | 0.80 | PIK3CG (0.47) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 | |
| SCHEMBL2959715 | 0.79 | PIK3CG (0.43) | PIK3CGPIK3CAPRKDCCYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2357179-A1 | Thiazol-2-yl organic compounds | Novartis AG (CH) | 2011-08-17 | — | — | EP | claimed |
| US-7754746-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-07-13 | — | — | US | claimed |
| CN-101374823-A | Organic compounds | NOVARTIS AG (CH) | 2009-02-25 | — | — | CN | claimed |