Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13141369 | 0.86 | PTPN1 (0.50) | PTPN1TDP1L3MBTL1SMN1; SMN2NPSR1 | |
| SCHEMBL12697638 | 0.86 | PLA2G4B (0.56) | PTPN1SMN1; SMN2KDM4EPSEN1PSEN2 | |
| SCHEMBL12687790 | 0.85 | SMN1; SMN2 (0.54) | PTPN1TDP1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL6225351 | 0.84 | PTPN1 (0.51) | PTPN1L3MBTL1SMN1; SMN2PSEN1PSEN2 | |
| SCHEMBL198467 | 0.84 | PTPN1 (0.60) | PTPN1L3MBTL1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL20441148 | 0.84 | PTPN1 (0.48) | PTPN1TDP1L3MBTL1SMN1; SMN2NPSR1 | |
| SCHEMBL23599248 | 0.83 | TDP1 (0.52) | TDP1L3MBTL1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL8752337 | 0.83 | CYP1A2 (0.52) | PTPN1SMN1; SMN2NPSR1LMNAKDM4E | |
| SCHEMBL3203038 | 0.83 | PTPN1 (0.52) | PTPN1L3MBTL1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL12687868 | 0.82 | HDAC6 (0.58) | PTPN1SMN1; SMN2KDM4ECYP1A2PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901653-B | Novel amide derivatives useful as diacylglycerol acyltransferase 2 inhibitors and uses thereof | 株式会社LG化学 | 2024-11-22 | — | — | CN | disclosed |
| EP-4074701-B1 | NOVEL AMIDE DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF | LG CHEMICAL LTD (KR) | 2023-12-13 | — | — | EP | disclosed |
| CN-114901653-A | Novel amide derivatives useful as diacylglycerol acyltransferase 2 inhibitors and uses thereof | 株式会社LG化学 | 2022-08-12 | — | — | CN | disclosed |
| WO-2021133038-A1 | NOVEL AMIDE DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF | 주식회사 엘지화학 | 2021-07-01 | — | — | WO | disclosed |