Sugi Predict

Sugi Predict / Compounds / SCHEMBL23600201

SCHEMBL23600201

SCHEMBL23600201

O=C1NC(=O)/C(=C/c2c[nH]c3ccncc23)O1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIM1 P11309 2/20 0.43
▸ PIM3 Q86V86 2/20 0.43
▸ HTR6 P50406 2/20 0.37
▸ HASPIN Q8TF76 2/20 0.36
▸ CCNT1 O60563 1/20 0.36
▸ CDK9 P50750 1/20 0.36
▸ KDR P35968 2/20 0.36
▸ FLT3 P36888 2/20 0.36
▸ GSK3B P49841 1/20 0.36
▸ PTGS1 P23219 1/20 0.36
▸ PTGS2 P35354 1/20 0.36
▸ PIP4K2A P48426 1/20 0.35
▸ NTRK1 P04629 2/20 0.35
▸ DAPK3 O43293 1/20 0.35
▸ PRKD3 O94806 1/20 0.35
▸ MAP4K4 O95819 1/20 0.35
▸ ABL1 P00519 1/20 0.35
▸ LCK P06239 1/20 0.35
▸ FYN P06241 1/20 0.35
▸ CSF1R P07333 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29764697 1.00 PIM1 (0.43) PIM1PIM3HTR6HASPINCCNT1
SCHEMBL23600200 0.90 PIM1 (0.43) PIM1PIM3HASPINCCNT1CDK9
SCHEMBL5576480 0.81 NTRK1 (0.53) PIM1KDRFLT3NTRK1DAPK3
SCHEMBL5576484 0.81 NTRK1 (0.53) PIM1KDRFLT3NTRK1DAPK3
SCHEMBL5576481 0.81 NTRK1 (0.53) PIM1KDRFLT3NTRK1DAPK3
SCHEMBL29764623 0.77 PIM1 (0.46) PIM1PIM3HTR6HASPINCCNT1
SCHEMBL23600235 0.77 PIM1 (0.46) PIM1PIM3HTR6HASPINCCNT1
SCHEMBL23600199 0.76 CHEK1 (0.56) PIM1PIM3HASPINCCNT1CDK9
SCHEMBL29764637 0.76 CGAS (0.51) PIM1PIM3HTR6HASPINCCNT1
SCHEMBL23600366 0.76 CGAS (0.51) PIM1PIM3HTR6HASPINCCNT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230129364-A1 PYRROLIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BETA-AMYLOID OR TAU PROTEIN-ASSOCIATED DISEASES CONTAINING SAME DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION (KR) 2023-04-27 — — US disclosed
US-20230129364-A1 PYRROLIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BETA-AMYLOID OR TAU PROTEIN-ASSOCIATED DISEASES CONTAINING SAME DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION (KR) 2023-04-27 — — US disclosed
EP-4083037-A1 PYRROLIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BETA-AMYLOID OR TAU PROTEIN-ASSOCIATED DISEASES CONTAINING SAME Yonsei University, University-Industry Foundation(UIF). (KR) 2022-11-02 — — EP disclosed
WO-2021133037-A1 PYRROLIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BETA-AMYLOID OR TAU PROTEIN-ASSOCIATED DISEASES CONTAINING SAME 연세대학교 산학협력단 2021-07-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230129364-A1 PYRROLIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BETA-AMYLOID OR TAU PROTEIN-ASSOCIATED DISEASES CONTAINING SAME MAPT, APP, PRNP PIM1 3071/4885PIM3 3597/4885HTR6 4584/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.