Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 20/20 | 0.92 |
| ▸ | CHRM2 | P08172 | 16/20 | 0.92 |
| ▸ | CHRM1 | P11229 | 16/20 | 0.92 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.71 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.71 |
| ▸ | TACR1 | P25103 | 2/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.71 |
| ▸ | HRH1 | P35367 | 2/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5978127 | 1.00 | CHRM3 (0.92) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL155126 | 0.99 | CHRM3 (0.92) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL4558111 | 0.99 | CHRM3 (0.92) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5979178 | 0.96 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5977160 | 0.96 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5976377 | 0.96 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL1234717 | 0.95 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5978626 | 0.95 | CHRM3 (0.98) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5979058 | 0.95 | CHRM3 (0.98) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL1234906 | 0.95 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117542-A1 | COMBINATIONS OF BETA- 2 -ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE | AstraZeneca AB (SE) | 2009-11-18 | — | — | EP | claimed |
| WO-2008096111-A1 | COMBINATIONS OF BETA- 2 -ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | WO | claimed |
| EP-1353919-B1 | NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | ALMIRALL PRODESFARMA AG (CH) | 2006-07-26 | — | — | EP | claimed |
| EP-2117542-B1 | COMBINATIONS OF BETA- 2 -ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE | ASTRAZENECA AB (SE) | 2011-08-17 | — | — | EP | disclosed |
| EP-2210614-A1 | Combinations comprising antimuscarinic agents and PDE4 inhibitors | Almirall S.A. (ES) | 2010-07-28 | — | — | EP | disclosed |
| EP-2117542-A1 | COMBINATIONS OF BETA- 2 -ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE | AstraZeneca AB (SE) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008096111-A1 | COMBINATIONS OF BETA- 2 -ADRENOCEPTOR AGONISTIC BENZOTHIAZOLONE | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | WO | disclosed |
| EP-1905451-A1 | Combinations comprising antimuscarinic agents and corticosteroids | Laboratorios Almirall, S.A. (ES) | 2008-04-02 | — | — | EP | disclosed |
| EP-1891974-A1 | Combinations comprising antimuscarinic agents and PDE4 inhibitors | Laboratorios Almirall, S.A. (ES) | 2008-02-27 | — | — | EP | disclosed |