Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.82 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.82 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.82 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.82 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.82 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.82 |
| ▸ | PFKP | Q01813 | 1/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.82 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.82 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.82 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23604930 | 1.00 | MTOR (0.82) | MTORPIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL23604917 | 0.98 | MTOR (0.82) | MTORPIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL23604916 | 0.98 | MTOR (0.82) | MTORPIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL22449927 | 0.96 | MTOR (0.83) | MTORPIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL22594118 | 0.93 | MTOR (0.83) | MTORPIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL22449816 | 0.93 | MTOR (0.83) | MTORPIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL22594121 | 0.93 | MTOR (0.83) | MTORPIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL23604919 | 0.92 | MTOR (0.82) | MTORPIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL23604918 | 0.92 | MTOR (0.82) | MTORPIK3CAPIK3CDPIK3R1PIK3CB | |
| Vistusertib SCHEMBL20734874 | 0.91 | MTOR (1.00) | MTORPIK3CAPIK3CDPIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133509-A1 | HETEROCYCLIC COMPOUNDS AS MTOR INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2021-07-01 | — | — | WO | disclosed |