Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.79 |
| ▸ | LCK | P06239 | 1/20 | 0.79 |
| ▸ | LYN | P07948 | 1/20 | 0.79 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.73 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.73 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.73 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.73 |
| ▸ | PRKDC | P78527 | 14/20 | 0.73 |
| ▸ | EGFR | P00533 | 15/20 | 0.69 |
| ▸ | KDR | P35968 | 13/20 | 0.69 |
| ▸ | ABL1 | P00519 | 13/20 | 0.69 |
| ▸ | HCK | P08631 | 13/20 | 0.69 |
| ▸ | SRC | P12931 | 13/20 | 0.69 |
| ▸ | MTOR | P42345 | 13/20 | 0.69 |
| ▸ | EPHB4 | P54760 | 13/20 | 0.69 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.66 |
| ▸ | RET | P07949 | 2/20 | 0.64 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.63 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19335138 | 1.00 | BTK (0.79) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL19335172 | 1.00 | BTK (0.79) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL22364036 | 1.00 | BTK (0.79) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL19335162 | 0.99 | BTK (0.80) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL19335163 | 0.96 | BTK (0.77) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL19335161 | 0.93 | BTK (0.72) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL23997156 | 0.90 | LCK (0.71) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL17713980 | 0.90 | BTK (0.98) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL30586962 | 0.88 | BTK (1.00) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL6431516 | 0.88 | BTK (1.00) | BTKLCKLYNPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE48175-E1 | Hydrophobically tagged small molecules as inducers of protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-08-25 | — | — | US | disclosed |
| EP-2534151-B1 | 8-METHYL-1-PHENYL-IMIDAZOL[1,5-A]PYRAZINE COMPOUNDS | MERCK SHARP & DOHME (NL) | 2018-11-14 | — | — | EP | disclosed |
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-04-05 | — | — | US | disclosed |
| US-9758522-B2 | Hydrophobically tagged small molecules as inducers of protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-09-12 | — | — | US | disclosed |
| US-8658794-B2 | 8-methyl-1-phenyl-imidazol[1,5-a]pyrazine compounds as Lck inhibitors and uses thereof | MERCK SHARP & DOHME B.V. (NL) | 2014-02-25 | — | — | US | disclosed |
| EP-2534151-A1 | 8-METHYL-1-PHENYL-IMIDAZOL[1,5-A]PYRAZINE COMPOUNDS | MSD Oss B.V. (NL) | 2012-12-19 | — | — | EP | disclosed |
| US-20120309966-A1 | 8-METHYL-1-PHENYL-IMIDAZOL[1,5-A]PYRAZINE COMPOUNDS | N.V. ORGANON (NL) | 2012-12-06 | — | — | US | disclosed |
| WO-2011095556-A1 | 8-METHYL-1-PHENYL-IMIDAZOL[1,5-A]PYRAZINE COMPOUNDS | N.V. ORGANON (NL) | 2011-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309966-A1 | 8-METHYL-1-PHENYL-IMIDAZOL[1,5-A]PYRAZINE COMPOUNDS | LCK, ZAP70, FYN | BTK 29/4885LCK 1/4885LYN 11/4885 |
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | MYC, TP53, MDM2 | BTK 2764/4885LCK 401/4885LYN 638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.