Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.44 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 10/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20286068 | 0.87 | CDK2 (0.50) | CDK2CSNK2A1CCNT1CCNKCCNE1 | |
| SCHEMBL20549662 | 0.87 | CDK2 (0.58) | CDK2CSNK2A1CCNT1CCNKCCNE1 | |
| SCHEMBL18313115 | 0.87 | CDK2 (0.58) | CDK2CSNK2A1CCNT1CCNKCCNE1 | |
| SCHEMBL21472931 | 0.85 | CSNK2A1 (0.63) | CDK2CSNK2A1CCNT1CCNKCCNE1 | |
| SCHEMBL20549734 | 0.84 | CDK2 (0.48) | CDK2CSNK2A1CSNK2A2CSNK2BGSK3B | |
| SCHEMBL20549736 | 0.84 | CDK2 (0.48) | CDK2CSNK2A1CSNK2A2CSNK2BGSK3B | |
| SCHEMBL18313497 | 0.82 | CDK2 (0.53) | CDK2CSNK2A1CCNT1CCNKCCNE1 | |
| SCHEMBL20549702 | 0.82 | CDK2 (0.53) | CDK2CSNK2A1CCNT1CCNKCCNE1 | |
| SCHEMBL21473063 | 0.79 | CSNK2A1 (0.57) | CDK2CSNK2A1CCNT1CCNKCCNE1 | |
| SCHEMBL20549689 | 0.78 | CDK2 (0.54) | CDK2CSNK2A1CCNT1CCNKCCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133601-A1 | THE COMBINATION OF CYCLIN DEPENDENT KINASE 7 INHIBITOR AND IMMUNOTHERAPY FOR TREATMENT OF CANCER | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-07-01 | — | — | WO | disclosed |