Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 19/20 | 0.86 |
| ▸ | CCNH | P51946 | 19/20 | 0.86 |
| ▸ | CDK9 | P50750 | 18/20 | 0.86 |
| ▸ | CCNT1 | O60563 | 17/20 | 0.86 |
| ▸ | CCNK | O75909 | 16/20 | 0.86 |
| ▸ | CDK12 | Q9NYV4 | 16/20 | 0.86 |
| ▸ | CDK13 | Q14004 | 13/20 | 0.86 |
| ▸ | MNAT1 | P51948 | 13/20 | 0.86 |
| ▸ | CDK2 | P24941 | 11/20 | 0.86 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.86 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.86 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.55 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23609900 | 0.96 | CDK7 (0.79) | CDK7CCNHCDK9CCNT1CCNK | |
| SCHEMBL20190873 | 0.93 | CDK7 (1.00) | CDK7CCNHCDK9CCNT1CCNK | |
| SCHEMBL20209077 | 0.93 | CDK7 (1.00) | CDK7CCNHCDK9CCNT1CCNK | |
| SCHEMBL20209064 | 0.93 | CDK7 (1.00) | CDK7CCNHCDK9CCNT1CCNK | |
| SCHEMBL20209095 | 0.91 | CDK7 (0.89) | CDK7CCNHCDK9CCNT1CCNK | |
| SCHEMBL20209059 | 0.86 | CDK7 (0.86) | CDK7CCNHCDK9CCNT1CCNK | |
| SCHEMBL20209066 | 0.85 | CDK7 (1.00) | CDK7CCNHCDK9CCNT1CCNK | |
| SCHEMBL18047352 | 0.85 | CDK7 (0.78) | CDK7CCNHCDK9CCNT1CCNK | |
| SCHEMBL18047354 | 0.85 | CDK7 (0.78) | CDK7CCNHCDK9CCNT1CCNK | |
| SCHEMBL18047326 | 0.85 | CDK7 (0.81) | CDK7CCNHCDK9CCNT1CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133601-A1 | THE COMBINATION OF CYCLIN DEPENDENT KINASE 7 INHIBITOR AND IMMUNOTHERAPY FOR TREATMENT OF CANCER | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-07-01 | — | — | WO | disclosed |