Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.63 |
| ▸ | CDK2 | P24941 | 3/20 | 0.63 |
| ▸ | CDK1 | P06493 | 2/20 | 0.63 |
| ▸ | GSK3A | P49840 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2339971 | 0.86 | GSK3B (0.70) | GSK3BCDK2CDK1MAPK1 | |
| SCHEMBL2361722 | 0.83 | GSK3B (0.62) | GSK3BCDK2CDK1GSK3A | |
| SCHEMBL4393025 | 0.83 | GSK3B (0.67) | GSK3BCDK2CDK1GSK3AMAPK1 | |
| SCHEMBL2335118 | 0.83 | GSK3B (0.67) | GSK3BCDK2CDK1MAPK1CYP1A2 | |
| SCHEMBL4384920 | 0.83 | GSK3B (0.67) | GSK3BCDK2CDK1 | |
| SCHEMBL2360845 | 0.81 | GSK3B (0.67) | GSK3BCDK2CDK1MAPK1CYP1A2 | |
| SCHEMBL2331113 | 0.81 | GSK3B (0.73) | GSK3BCDK2CDK1GSK3AMAPK1 | |
| SCHEMBL4380218 | 0.81 | GSK3B (0.70) | GSK3BCDK2CDK1MAPK1 | |
| SCHEMBL4380398 | 0.80 | GSK3B (0.62) | GSK3BCDK2CDK1 | |
| SCHEMBL4379033 | 0.80 | GSK3B (0.62) | GSK3BCDK2CDK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572200-B1 | AMINOINDAZOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2011-08-17 | — | — | EP | claimed |