Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.47 |
| ▸ | CCNK | O75909 | 7/20 | 0.45 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.45 |
| ▸ | CDK2 | P24941 | 5/20 | 0.45 |
| ▸ | CDK9 | P50750 | 5/20 | 0.45 |
| ▸ | CDK7 | P50613 | 4/20 | 0.45 |
| ▸ | CCNH | P51946 | 4/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2232040 | 1.00 | IRAK4 (0.47) | IRAK4CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL12454041 | 0.88 | CCNT1 (0.46) | IRAK4CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL2231095 | 0.85 | CDK7 (0.48) | IRAK4CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL15167147 | 0.85 | CCNT1 (0.62) | IRAK4CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL2231093 | 0.85 | CDK7 (0.48) | IRAK4CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL15167149 | 0.85 | CCNT1 (0.62) | IRAK4CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL2345601 | 0.84 | IRAK4 (0.57) | IRAK4CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL2345606 | 0.84 | IRAK4 (0.57) | IRAK4CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL2234477 | 0.84 | PIM1 (0.46) | IRAK4CCNT1CDK2CDK9FLT3 | |
| SCHEMBL2234475 | 0.84 | PIM1 (0.46) | IRAK4CCNT1CDK2CDK9FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536728-A1 | PYRAZOLE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011101161-A1 | PYRAZOLE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-08-25 | — | — | WO | disclosed |