SCHEMBL23622150

SCHEMBL23622150

c1ccc([Si](c2ccccc2)(c2cccc(-c3nc(-n4c5ccccc5c5ccccc54)cc(-n4c5ccccc5c5ccccc54)n3)c2)c2cccc(-c3nc(-n4c5ccccc5c5ccccc54)nc(-n4c5ccccc5c5ccccc54)n3)c2)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.36
KDM4E B2RXH2 2/20 0.33
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ABCB1 P08183 1/20 0.32
ABCG2 Q9UNQ0 1/20 0.32
MAPT P10636 2/20 0.32
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
HSD17B10 Q99714 1/20 0.32
NR1I3 Q14994 2/20 0.30
CYP1A2 P05177 2/20 0.30
CYP3A4 P08684 2/20 0.30
VDR P11473 1/20 0.30
CYP2C9 P11712 1/20 0.30
CYP2B6 P20813 1/20 0.30
AHR P35869 1/20 0.30
HPGD P15428 2/20 0.30
LMNA P02545 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23622630 0.95 HTT (0.39) HTTKDM4EATML3MBTL1ABCB1
SCHEMBL22039850 0.95 HTT (0.39) HTTKDM4EATML3MBTL1ABCB1
SCHEMBL30846074 0.93 KDM4E (0.37) KDM4EATML3MBTL1ABCB1ABCG2
SCHEMBL22038577 0.93 KDM4E (0.37) KDM4EATML3MBTL1ABCB1ABCG2
SCHEMBL23622549 0.93 KDM4E (0.37) KDM4EATML3MBTL1ABCB1ABCG2
SCHEMBL23622236 0.93 KDM4E (0.31) KDM4EATML3MBTL1ABCB1ABCG2
SCHEMBL25449302 0.92 HTT (0.38) HTTKDM4EATML3MBTL1MAPT
SCHEMBL23622200 0.92 MAPT (0.36) HTTKDM4EMAPTTSHRMAPK1
SCHEMBL24900340 0.91 KDM4E (0.35) KDM4EATML3MBTL1ABCB1ABCG2
SCHEMBL25449265 0.91 KDM4E (0.35) KDM4EATML3MBTL1ABCB1ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230363254-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-09 US disclosed
US-11716899-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-08-01 US disclosed
US-11716899-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-08-01 US disclosed
US-20210210700-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2021-07-08 US disclosed