Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.55 |
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | LDHB | P07195 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2275541 | 0.84 | SYK (0.68) | AAK1SYKCYP2C9JAK2JAK1 | |
| SCHEMBL14655367 | 0.76 | CYP2C9 (0.53) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2277066 | 0.75 | SYK (0.67) | AAK1SYKCYP2C9JAK2JAK1 | |
| SCHEMBL2282760 | 0.74 | SYK (0.69) | AAK1SYKCYP2C9LMNAKDM4E | |
| SCHEMBL2277342 | 0.74 | JAK3 (0.48) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2275862 | 0.73 | SYK (0.67) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2276549 | 0.72 | SYK (0.69) | AAK1SYKCYP2C9JAK2JAK1 | |
| SCHEMBL3372895 | 0.72 | AXL (0.51) | SYKCYP2C9JAK2JAK3LDHA | |
| SCHEMBL2280570 | 0.71 | SYK (0.67) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2275868 | 0.71 | SYK (0.49) | SYKCYP2C9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |