SCHEMBL23622932

SCHEMBL23622932

Cc1cc(N)cnc1N1CCO[C@@H](C)C1

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
LRRK2 Q5S007 7/20 0.46
FFAR2 O15552 12/20 0.42
STK3 Q13188 1/20 0.39
STK26 Q9P289 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13724161 1.00 LRRK2 (0.46) LRRK2FFAR2STK3STK26
SCHEMBL23623185 0.85 LRRK2 (0.43) LRRK2FFAR2STK3STK26
SCHEMBL23623170 0.85 LRRK2 (0.43) LRRK2FFAR2STK3STK26
SCHEMBL30205934 0.83 LRRK2 (0.43) LRRK2FFAR2STK3STK26
SCHEMBL29173621 0.83 LRRK2 (0.43) LRRK2FFAR2STK3STK26
SCHEMBL29209033 0.82 PIK3CA (0.43)
SCHEMBL29209035 0.82 PIK3CA (0.43)
SCHEMBL29208999 0.82 PIK3CA (0.43)
SCHEMBL2144542 0.79 KDM4E (0.46) LRRK2STK3
SCHEMBL13724403 0.78 LRRK2 (0.41) LRRK2FFAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230127839-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2023-04-27 US disclosed
US-20230127839-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2023-04-27 US disclosed
WO-2021138434-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC. (US) 2021-07-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230127839-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 LRRK2 99/4885FFAR2 3521/4885STK3 2162/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.