Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.62 |
| ▸ | CDK1 | P06493 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.54 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.54 |
| ▸ | CDK7 | P50613 | 11/20 | 0.52 |
| ▸ | CCNH | P51946 | 10/20 | 0.52 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.52 |
| ▸ | CDK9 | P50750 | 5/20 | 0.52 |
| ▸ | CDK2 | P24941 | 4/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | CDK12 | Q9NYV4 | 6/20 | 0.52 |
| ▸ | CCNK | O75909 | 5/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.52 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23624995 | 0.90 | EGFR (0.62) | EGFRCDK1KDRCDK5CDK5R1 | |
| SCHEMBL23624971 | 0.84 | ALK (0.62) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL23624959 | 0.84 | EGFR (0.64) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL23624957 | 0.82 | EGFR (0.52) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL23625086 | 0.82 | EGFR (0.52) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL20204774 | 0.81 | EGFR (0.67) | EGFRCDK1KDRCDK5CDK5R1 | |
| SCHEMBL29613510 | 0.81 | EGFR (0.67) | EGFRCDK1KDRCDK5CDK5R1 | |
| SCHEMBL23625025 | 0.80 | JAK2 (0.55) | EGFRCDK1KDRCDK5CDK5R1 | |
| SCHEMBL23624963 | 0.80 | EGFR (0.51) | EGFRCDK1KDRCDK7CCNH | |
| SCHEMBL23625001 | 0.80 | EGFR (0.65) | EGFRCDK1KDRCDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021138392-A1 | AMINOPYRIMIDINE COMPOUNDS | TYRA BIOSCIENCES, INC. (US) | 2021-07-08 | — | — | WO | disclosed |