Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 17/20 | 0.90 |
| ▸ | RPS6KA2 | Q15349 | 8/20 | 0.90 |
| ▸ | RPS6KA1 | Q15418 | 3/20 | 0.78 |
| ▸ | RPS6KA6 | Q9UK32 | 3/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19252845 | 0.95 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL19252963 | 0.94 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL1988119 | 0.89 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL1993377 | 0.89 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL19278647 | 0.88 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL19252896 | 0.88 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| Hydrochloric Acid SCHEMBL19252861 | 0.87 | RPS6KA3 (0.98) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| Hydrochloric Acid SCHEMBL31669012 | 0.87 | RPS6KA3 (0.98) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| Hydrochloric Acid SCHEMBL31669013 | 0.87 | RPS6KA3 (0.98) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| Hydrochloric Acid SCHEMBL29477399 | 0.87 | RPS6KA3 (0.98) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848373-A1 | N-(1-((HETEROCYCLYL)METHYL)-1H-PYRAZOL-4-YL)-6-OXO-6,7,8,9- TETRAHYDROPYRIDO[3',2':4,5]PYRROLO[L,2-A]PYRAZINE-2-CARBOXAMIDE DERIVATIVES AS P90 RIBOSOMAL S6 KINASE (RSK) INHIBITORS FOR TREATING CANCER | Phoenix Molecular Designs (CA) | 2021-07-14 | — | — | EP | disclosed |