Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | SYK | P43405 | 3/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | FOS | P01100 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30879308 | 0.87 | MAPT (0.80) | MAPTLMNASYKMAPK1HTT | |
| SCHEMBL6338112 | 0.86 | SYK (0.80) | MAPTLMNASYKMAPK1HTT | |
| SCHEMBL7797838 | 0.84 | SYK (0.80) | MAPTLMNASYKMAPK1HTT | |
| SCHEMBL1353552 | 0.84 | SYK (1.00) | MAPTLMNASYKMAPK1HTT | |
| SCHEMBL1313596 | 0.84 | SYK (0.79) | MAPTLMNASYKMAPK1HTT | |
| SCHEMBL22165397 | 0.82 | MAPT (0.75) | MAPTLMNASYKMAPK1HTT | |
| SCHEMBL2627146 | 0.81 | SYK (0.75) | MAPTLMNASYKMAPK1HTT | |
| SCHEMBL30878949 | 0.80 | SYK (0.74) | MAPTLMNASYKMAPK1HTT | |
| SCHEMBL23633036 | 0.78 | HTT (0.47) | MAPTLMNASYKMAPK1HTT | |
| SCHEMBL14800780 | 0.78 | MAPT (0.60) | MAPTLMNASYKALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901664-B | Pyridone compounds and uses thereof | 南京再明医药有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-114901664-A | Pyridone compound and application thereof | 江苏先声药业有限公司 | 2022-08-12 | — | — | CN | disclosed |
| WO-2021139775-A1 | PYRIDONE COMPOUND AND APPLICATION | 江苏先声药业有限公司 | 2021-07-15 | — | — | WO | disclosed |
| WO-2021139775-A1 | PYRIDONE COMPOUND AND APPLICATION | 江苏先声药业有限公司 | 2021-07-15 | — | — | WO | disclosed |