Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 20/20 | 0.79 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.79 |
| ▸ | MAPK6 | Q16659 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17837180 | 1.00 | MAPK1 (0.79) | MAPK1MAPK3MAPK6 | |
| Temuterkib SCHEMBL17837273 | 0.88 | MAPK1 (1.00) | MAPK1MAPK3MAPK6 | |
| SCHEMBL17837201 | 0.88 | MAPK1 (0.74) | MAPK1MAPK3MAPK6 | |
| SCHEMBL17881857 | 0.88 | MAPK1 (0.74) | MAPK1MAPK3MAPK6 | |
| SCHEMBL17837306 | 0.85 | MAPK1 (0.94) | MAPK1MAPK3 | |
| SCHEMBL17837212 | 0.84 | MAPK1 (0.86) | MAPK1MAPK3MAPK6 | |
| Temuterkib SCHEMBL28928408 | 0.84 | MAPK1 (0.91) | MAPK1MAPK3 | |
| SCHEMBL17837258 | 0.84 | MAPK1 (0.79) | MAPK1MAPK3MAPK6 | |
| SCHEMBL17837246 | 0.83 | MAPK1 (0.83) | MAPK1MAPK3MAPK6 | |
| SCHEMBL17856228 | 0.83 | MAPK1 (0.83) | MAPK1MAPK3MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE48635-E1 | ERK inhibitors | ELI LILLY AND COMPANY (US) | 2021-07-13 | — | — | US | disclosed |