Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2363497 | 0.94 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2270679 | 0.90 | PIK3CD (0.64) | PIK3CDPIK3CGPIK3CBPIK3CALMNA | |
| SCHEMBL2273155 | 0.80 | PIK3CD (0.69) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2275252 | 0.78 | PIK3CD (0.56) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL15222419 | 0.77 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2674384 | 0.74 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL15334625 | 0.73 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2271455 | 0.73 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3CBPIK3CASMN1; SMN2 | |
| SCHEMBL2274279 | 0.72 | PIK3CD (0.51) | PIK3CDPIK3CGPIK3CBPIK3CASMN1; SMN2 | |
| SCHEMBL2272826 | 0.72 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101429-A1 | PYRIDO[3,2-D]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | disclosed |