Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22745311 | 0.88 | POLB (0.34) | POLBGAAKDM4EALDH1A1HPGD | |
| SCHEMBL19935363 | 0.84 | POLB (0.38) | POLBGAAKDM4EALDH1A1HPGD | |
| SCHEMBL19935294 | 0.82 | POLB (0.33) | POLBGAAKDM4EALDH1A1HPGD | |
| SCHEMBL22745132 | 0.82 | POLB (0.33) | POLBGAAKDM4EALDH1A1HPGD | |
| SCHEMBL22745380 | 0.81 | POLB (0.32) | POLBGAA | |
| SCHEMBL22745131 | 0.80 | POLB (0.31) | POLBGAAKDM4EALDH1A1HPGD | |
| SCHEMBL22745500 | 0.77 | POLB (0.40) | POLBGAAKDM4EALDH1A1HPGD | |
| SCHEMBL22745249 | 0.76 | POLB (0.38) | POLBGAAKDM4EALDH1A1HPGD | |
| SCHEMBL22193785 | 0.75 | POLB (0.36) | POLBGAAKDM4EALDH1A1HPGD | |
| SCHEMBL19935299 | 0.74 | POLB (0.38) | POLBGAAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848372-A1 | FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2021-07-14 | — | — | EP | disclosed |