Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10389968 | 0.79 | FGFR1 (0.36) | FGFR1FGFR4SLC22A12PRMT5WDR77 | |
| SCHEMBL21822975 | 0.78 | ADORA2A (0.41) | FGFR1FGFR4SLC22A12NOTUM | |
| SCHEMBL23193094 | 0.78 | FGFR1 (0.39) | FGFR1FGFR4SLC22A12PRMT5WDR77 | |
| SCHEMBL3401964 | 0.75 | TNF (0.45) | FGFR1FGFR4SLC22A12KMT2A | |
| SCHEMBL4255524 | 0.75 | SLC22A12 (0.41) | FGFR1FGFR4SLC22A12KMT2AALDH1A1 | |
| SCHEMBL100735 | 0.74 | SLC22A12 (0.37) | FGFR1FGFR4SLC22A12PRMT5WDR77 | |
| SCHEMBL7024298 | 0.74 | FGFR1 (0.38) | FGFR1FGFR4SLC22A12KMT2AALDH1A1 | |
| SCHEMBL27849552 | 0.72 | KDM4E (0.44) | FGFR1FGFR4SLC22A12NOTUM | |
| SCHEMBL4015921 | 0.72 | FGFR1 (0.40) | FGFR1FGFR4SLC22A12NOTUM | |
| SCHEMBL16363382 | 0.72 | FGFR1 (0.43) | FGFR1FGFR4SLC22A12PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536687-B1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | DANA FARBER CANCER INST INC (US) | 2021-07-14 | — | — | EP | disclosed |