Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 19/20 | 0.53 |
| ▸ | BCR | P11274 | 19/20 | 0.53 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.46 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401524 | 0.84 | ABL1 (0.56) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3398709 | 0.80 | ABL1 (0.62) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3399944 | 0.78 | ABL1 (0.58) | ABL1BCR | |
| SCHEMBL16331109 | 0.78 | ABL1 (0.62) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3400258 | 0.78 | ABL1 (0.64) | ABL1BCR | |
| SCHEMBL23637123 | 0.76 | ABL1 (0.57) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3400367 | 0.75 | ABL1 (0.64) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL18696341 | 0.74 | ABL1 (0.69) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3396839 | 0.71 | ABL1 (0.55) | ABL1BCR | |
| SCHEMBL29533674 | 0.71 | ABL1 (0.47) | ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536687-B1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | DANA FARBER CANCER INST INC (US) | 2021-07-14 | — | — | EP | disclosed |