Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27437381 | 0.76 | HRH3 (0.39) | HRH3CCR2KCNH2 | |
| SCHEMBL17264258 | 0.76 | HRH3 (0.45) | HRH3CCR2KCNH2 | |
| SCHEMBL21157892 | 0.76 | HRH3 (0.45) | HRH3CCR2KCNH2 | |
| SCHEMBL22996703 | 0.75 | HRH3 (0.49) | HRH3CCR2KCNH2 | |
| SCHEMBL18513025 | 0.74 | HRH3 (0.51) | HRH3CCR2KCNH2 | |
| SCHEMBL26869129 | 0.74 | HRH3 (0.51) | HRH3CCR2KCNH2 | |
| SCHEMBL23103966 | 0.71 | HRH3 (0.46) | HRH3CCR2KCNH2 | |
| SCHEMBL23107070 | 0.71 | HRH3 (0.46) | HRH3CCR2KCNH2 | |
| SCHEMBL23102841 | 0.71 | HRH3 (0.46) | HRH3CCR2KCNH2 | |
| SCHEMBL16000539 | 0.69 | HRH3 (0.53) | HRH3CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265093-A1 | BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF THE HUMAN SEROTONIN RECEPTOR 2C (5-HT2C) | NORTHWESTERN UNIVERSITY | 2023-08-24 | — | — | US | disclosed |
| US-20210214352-A1 | BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF THE HUMAN SEROTONIN RECEPTOR 2C (5-HT2C) | NORTHWESTERN UNIVERSITY | 2021-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210214352-A1 | BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF THE HUMAN SEROTONIN RECEPTOR 2C (5-HT2C) | HTR2C, HTR3B, HTR2A | HRH3 206/4885CCR2 299/4885KCNH2 2912/4885 |
| US-20230265093-A1 | BETA-CARBOLINES AS POSITIVE ALLOSTERIC MODULATORS OF THE HUMAN SEROTONIN RECEPTOR 2C (5-HT2C) | HTR2C, HTR3B, HTR2A | HRH3 206/4885CCR2 299/4885KCNH2 2912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.