Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2363974 | 1.00 | PDPK1 (0.51) | PDPK1LMNASMN1; SMN2POLBTDP1 | |
| SCHEMBL658503 | 0.83 | PDPK1 (0.73) | PDPK1SMN1; SMN2NPC1GPR52ALDH1A1 | |
| SCHEMBL658504 | 0.83 | PDPK1 (0.73) | PDPK1SMN1; SMN2NPC1GPR52ALDH1A1 | |
| SCHEMBL658502 | 0.83 | PDPK1 (0.73) | PDPK1SMN1; SMN2NPC1GPR52ALDH1A1 | |
| SCHEMBL10252979 | 0.80 | PDPK1 (0.60) | PDPK1ALDH1A1MAPTHTTNPSR1 | |
| SCHEMBL2308099 | 0.78 | PDPK1 (0.51) | PDPK1LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2308096 | 0.78 | PDPK1 (0.51) | PDPK1LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL10252838 | 0.77 | PDPK1 (0.46) | PDPK1LMNASMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL17451350 | 0.77 | PDPK1 (0.54) | PDPK1SMN1; SMN2TDP1NPC1ALDH1A1 | |
| SCHEMBL17451351 | 0.77 | PDPK1 (0.54) | PDPK1SMN1; SMN2TDP1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |