Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 4/20 | 0.66 |
| ▸ | RAB9A | P51151 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.50 |
| ▸ | CCNC | P24863 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14795046 | 0.92 | POLB (0.61) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL16147933 | 0.91 | POLB (0.61) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL13096996 | 0.85 | POLB (0.68) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL6952645 | 0.85 | POLB (0.72) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL13946706 | 0.84 | POLB (0.56) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL20163507 | 0.84 | POLB (0.56) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2229518 | 0.84 | POLB (0.56) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL22434503 | 0.84 | POLB (0.60) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL3562876 | 0.84 | POLB (0.56) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8469734 | 0.83 | POLB (0.51) | POLBNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848367-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-07-14 | — | — | EP | disclosed |