Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 17/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 17/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23640500 | 1.00 | DDB1 (0.42) | DDB1CRBNSIRT1IDO1SIRT2 | |
| SCHEMBL24938749 | 0.92 | DDB1 (0.45) | DDB1CRBNIDO1 | |
| SCHEMBL24303027 | 0.87 | DDB1 (0.42) | DDB1CRBN | |
| SCHEMBL24303033 | 0.87 | DDB1 (0.42) | DDB1CRBN | |
| SCHEMBL23639961 | 0.87 | DDB1 (0.52) | DDB1CRBN | |
| SCHEMBL23640324 | 0.87 | IDO1 (0.44) | DDB1CRBNIDO1 | |
| SCHEMBL24303034 | 0.87 | CRBN (0.41) | DDB1CRBN | |
| SCHEMBL23639962 | 0.87 | DDB1 (0.52) | DDB1CRBN | |
| SCHEMBL23640481 | 0.87 | DDB1 (0.41) | DDB1CRBNIDO1 | |
| SCHEMBL23640482 | 0.87 | DDB1 (0.41) | DDB1CRBNIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848367-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-07-14 | — | — | EP | disclosed |