⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2556849 | 0.79 | — | — | |
| SCHEMBL7725 | 0.79 | — | — | |
| SCHEMBL137217 | 0.72 | — | — | |
| SCHEMBL5728116 | 0.72 | — | — | |
| Hydrogen Sulfide SCHEMBL11755188 | 0.72 | — | — | |
| SCHEMBL17222435 | 0.72 | — | — | |
| SCHEMBL5438089 | 0.72 | — | — | |
| SCHEMBL6967583 | 0.72 | — | — | |
| SCHEMBL9065633 | 0.72 | — | — | |
| Ammonia Solution, Strong SCHEMBL3894177 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858387-A1 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS | Seagen Inc. (US) | 2021-08-04 | — | — | EP | disclosed |
| EP-3778917-A2 | MULTISPECIFIC ANTIBODIES, ANTIBODY ANALOGS, COMPOSITIONS, AND METHODS | F. Hoffmann-La Roche AG (CH) | 2021-02-17 | — | — | EP | disclosed |
| US-10918735-B2 | Substituted pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones for cancer treatment | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-02-16 | — | — | US | disclosed |
| US-20200347149-A1 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS | SEAGEN INC. | 2020-11-05 | — | — | US | disclosed |
| US-10808039-B2 | Monomethylvaline compounds capable of conjugation to ligands | SEATTLE GENETICS INC. (US) | 2020-10-20 | — | — | US | disclosed |
| US-10584181-B2 | Methods of making and using multispecific antibody panels and antibody analog panels | GENENTECH, INC. (US) | 2020-03-10 | — | — | US | disclosed |
| US-20190338045-A1 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS | SEAGEN INC. | 2019-11-07 | — | — | US | disclosed |
| US-10414826-B2 | Monomethylvaline compounds capable of conjugation to ligands | SEATTLE GENETICS, INC. (US) | 2019-09-17 | — | — | US | disclosed |
| US-20190255187-A1 | SUBSTITUTED PYRAZINO[1',2':1,5]PYRROLO[2,3-B]INDOLE-1,4-DIONES FOR CANCER TREATMENT | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-08-22 | — | — | US | disclosed |
| EP-3498289-A1 | MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS | Seattle Genetics, Inc. (US) | 2019-06-19 | — | — | EP | disclosed |
| US-20060182751-A1 | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use | GENENTECH, INC. (US) | 2006-08-17 | — | — | US | disclosed |
| WO-2006060533-A2 | CONJUGATES OF 1, 8-BIS-NAPHTHALIMIDES WITH AN ANTIBODY | GENENTECH, INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| WO-2006034488-A2 | CYSTEINE ENGINEERED ANTIBODIES AND CONJUGATES | GENENTECH, INC. (US) | 2006-03-30 | — | — | WO | disclosed |
| US-20050276812-A1 | maytansinoid drug moieties covalently linked by a linker to an antibody which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors; cancer | GENENTECH, INC. (US) | 2005-12-15 | — | — | US | disclosed |
| WO-2005117986-A2 | ANTIBODY DRUG CONJUGATES AND METHODS | GENENTECH, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
| WO-2005101017-A1 | MASS SPECTROMETRY OF ANTIBODY CONJUGATES | GENENTECH, INC. (US) | 2005-10-27 | — | — | WO | disclosed |
| US-20050238649-A1 | Auristatin and dolastatin analogs; for treating cancer, autoimmune diseases and infectious diseases | SEATTLE GENETICS, INC. (US) | 2005-10-27 | — | — | US | disclosed |
| US-20050232929-A1 | Mass spectrometry of antibody conjugates | GENENTECH, INC. | 2005-10-20 | — | — | US | disclosed |
| WO-2005081711-A2 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS | SEATTLE GENETICS, INC. (US) | 2005-09-09 | — | — | WO | disclosed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |