Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23643510 | 0.99 | POLB (0.41) | POLBAPEX1HTTTDP1ELANE | |
| SCHEMBL24244898 | 0.87 | ELANE (0.43) | POLBAPEX1HTTTDP1ELANE | |
| SCHEMBL23643474 | 0.87 | ELANE (0.46) | POLBHTTELANEKMT2AATM | |
| SCHEMBL23643499 | 0.86 | POLB (0.36) | POLBAPEX1HTTTDP1ELANE | |
| SCHEMBL23643493 | 0.85 | ELANE (0.44) | POLBTDP1ELANEKMT2AATM | |
| SCHEMBL23643503 | 0.85 | ELANE (0.44) | POLBAPEX1HTTTDP1ELANE | |
| SCHEMBL23643528 | 0.85 | POLB (0.38) | POLBAPEX1HTTTDP1ELANE | |
| SCHEMBL16559838 | 0.85 | POLB (0.44) | POLBAPEX1HTTTDP1ELANE | |
| SCHEMBL24440871 | 0.84 | POLB (0.43) | POLBAPEX1HTTTDP1ELANE | |
| SCHEMBL23643324 | 0.84 | HTT (0.40) | POLBAPEX1HTTTDP1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11760935-B2 | Polymerizable compounds | MERCK PATENT GMBH (DE) | 2023-09-19 | — | — | US | disclosed |
| US-11760935-B2 | Polymerizable compounds | MERCK PATENT GMBH (DE) | 2023-09-19 | — | — | US | disclosed |
| EP-4056667-B1 | LIQUID-CRYSTAL MEDIUM COMPRISING POLYMERIZABLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-08-02 | — | — | EP | disclosed |
| US-20230045041-A1 | POLYMERIZABLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-02-09 | — | — | US | disclosed |
| EP-3950670-A1 | POLYMERIZABLE COMPOUNDS | Merck Patent GmbH (DE) | 2022-02-09 | — | — | EP | disclosed |
| US-20210222067-A1 | LIQUID-CRYSTAL MEDIUM | MERCK PATENT GMBH (DE) | 2021-07-22 | — | — | US | disclosed |
| EP-3848436-A1 | LIQUID-CRYSTAL MEDIUM | Merck Patent GmbH (DE) | 2021-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11760935-B2 | Polymerizable compounds | PARG, PHOSPHO1, PARN | POLB 81/4885APEX1 894/4885HTT 359/4885 |
| US-20230045041-A1 | POLYMERIZABLE COMPOUNDS | PARG, PHOSPHO1, PARN | POLB 81/4885APEX1 894/4885HTT 359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.