Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.55 |
| ▸ | MYC | P01106 | 5/20 | 0.50 |
| ▸ | CTSB | P07858 | 3/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23645576 | 0.85 | DHODH (0.57) | DHODHMYCCTSBKLKB1PKM | |
| SCHEMBL23645577 | 0.84 | DHODH (0.51) | DHODHMYCCTSBKLKB1PKM | |
| SCHEMBL24060266 | 0.82 | DHODH (0.56) | DHODHMYCCTSBKLKB1PKM | |
| SCHEMBL1553215 | 0.81 | KDM4E (0.70) | MYCTDP1KDM4EALDH1A1MAPT | |
| SCHEMBL23645548 | 0.80 | DHODH (0.50) | DHODHMYCCTSBKLKB1PKM | |
| SCHEMBL2426286 | 0.80 | KDM4E (0.59) | DHODHTDP1KDM4EALDH1A1MEN1 | |
| SCHEMBL23645550 | 0.80 | DHODH (0.52) | DHODHMYCCTSBKLKB1PKM | |
| SCHEMBL22732563 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL23645549 | 0.79 | DHODH (0.51) | DHODHMYCCTSBKLKB1PKM | |
| SCHEMBL23644492 | 0.79 | DHODH (0.51) | DHODHMYCCTSBKLKB1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3615027-B1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECH LTD (IN) | 2021-07-14 | — | — | EP | disclosed |